You can easily access Lefkas by car, as it is one of the only two islands in Greece that has land access from the mainland! If you arrive in Athens, it is a 4.5 hour drive, or you can take the intercity bus (KTEL) directly to Lefkas for a 5 hour drive. If you come from Thessaloniki, you can use the Egnatia Highway and with a 4.5 hour drive you can enjoy the beaches of Lefkas! From Preveza (Aktion) airport it's only a 25 minute drive, with daily intercity bus connection as well!